Having listened to both the Empyrean 2 and HE1000SE and sold the HE1000SE a week later, I agree with most of his review.
I was in the market for fun, engaging, and neutral-bright but not sibilant headphones, easy to drive and available (
cough cough Modhouse Tungsten) to accompany my lush and superb Atrium. The HE1000SE somewhat fulfilled that niche, but the infamous Hifiman treble bothered me a lot, even with the Dekoni Hybrid pads. I also bought a subscription to Last.FM pro to help inform my purchase (picture below), and it was evident that I just couldn't stand using the HE1000SE for more energetic genres like electronic (DnB, EDM, trap) and pop. On top of this, the HE1000SE was unengaging (very impersonal and "cold" sounding) and uncomfortable (the bottom of the egg-shape pads kept digging into my jaw), had a "meh" build quality, and had the reputation of breaking down easily (Hifiman QC lol). The last issue was confirmed when it was DOA to a buyer, and if I hadn't been so lucky to track down the original owner for the receipt, I'd have had a $1500 pile of garbage returned to me.
None of this is to diminish WaveTheory's review (IMO his reviews are the best right now), but our music preference (he tends to use orchestral music in his evaluation) and what we wanted out of the headphones. I kept the Empyrean 2 due to its superior comfort, versatility, and engagement, while not being a complete slouch in technicalities (with the AA pads). If I exclusively listened to orchestra music and prioritized analytical listening, I'd have kept the HE1000SE. Also, I've been listening to the Empyrean 2 daily for about ~ 2 months now and haven't noticed any pressure build up in my ears with the Duo pads, but this is a YMMV, different in head-shape thing. As for the price tag, I could see how the MSRP is high given the "objective", but I kept the Empyrean 2 purely on the "subjective".
Nevertheless, when it comes to these kilo-bucks (or any) headphones, you need to listen to them yourself. I demoed the Empyrean 2 on an SS amp at my local store and knew that I'd love them on tubes. Reviews are helpful but they can only provide so much insight since the reviewer's sound preferences and head shape might be different from your own. I dislike the 6XX, the Focal Clear OG, and the Arya Stealth, and I'm about to sell the HD8000S, even though these are the reviewers' favorites.